Cross-contamination and safety
Cross-contamination poses a threat to the safety of both the people who will eventually take the drug and the employees who make it. Over the past 5 to 7 years, we’ve seen a rise in the toxicity levels of pharmaceutical ingredients. This is driven in part by growing demand for new advancements in medicine to combat diseases like Alzheimer’s disease and new forms of cancer. The side effects of these highly toxic ingredients can be serious, there is the potential for drug interaction, and they may cause severe adverse effects in certain populations. That’s why no one should even be exposed to them if not under a doctor’s care.Cross-contamination and purity
The relationship between these two factors is clear: contaminated is the opposite of pure. And an impure drug will likely also be unsafe and/or ineffective.Cross-contamination and effectiveness
Finally, beyond having an unintended effect, a cross-contaminated drug may not have its desired effect. This means the people taking the medication won’t receive the treatment that they need. If you’re lucky, ineffective medications are merely harmless to the people who take them. But, even so, they can result in a recall. Or worse. Earlier this year, a couple sued a company over ineffective fertility medication. And this study found that ineffective antimalarial, AIDS, and other drugs are at the root of a public health crisis in undeveloped countries.How to prevent dust cross-contamination
According to cGMPs, if a company discovers that a drug is contaminated, they must not distribute the product. They must also correct the problem that resulted in the contamination. If the contamination isn’t discovered until after the drug has been distributed, the company should issue a recall, which can have disastrous consequences, both financially and in terms of PR. Gerard Geiger, Nilfisk’s Business Development Manager for the Pharmaceutical industry, suggests a two-pronged approach to prevent dust cross-contamination.- First, identify the source of the contamination. The best way to prevent cross-contamination is to capture the dust as quickly as possible.
- Second, implement process controls. These may include equipment modifications, engineered control systems, or even building controls into the facility design.